Chemistry and Life

Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences.

Idelalisib, a phosphoinositide 3-kinase (PI3K) inhibitor

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From Wikimedia CommonsThis paper in the New England Journal of Medicine describes encouraging clinical results for idelalisib (in combination with the existing drug rituximab) for the treatment of leukemia.  Idelalisib is an inhibitor of phosphoinositide 3-kinase (PI3K), a target that has been of high interest in oncology drug discovery in recent years.  There is a lot of time and effort invested in this target with many pharmaceutical companies pursuing this line of research and development.  Idelalisib, as far as I am aware, is furthest along in clinical development so it is definitely good news to have this kind of positive validation in late stage clinical trials.

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One thought on “Idelalisib, a phosphoinositide 3-kinase (PI3K) inhibitor

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